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PLATELET DISORDERS - INTRODUCTION
Platelets, oval or rod-shaped cytoplasmic fragments about 2 to 4 microns in diameter, are derived from bone marrow megakaryocytes. Platelet disorders stemming from abnormalities of number (thrombocytopenia and thrombocytosis) or function (thrombasthenia end thrombocytopathia) impair vascular integrity and the coagulation mechanism. However, serious coagulopathy is likely only when large numbers of platelets are dysfunctional or deficient.
In thrombocytopenia, the most common platelet deficiency, the number of platelets is abnormally low (less than 150,000/mm3); nevertheless, overt bleeding doesn't generally develop until the count drops below 50,000/mm3. Thrombocytopenia may result from decreased bone marrow production of platelets related to aplastic anemia, leukemia, and vitamin B12 or folic acid deficiency; from accelerated destruction of platelets by the spleen; from exaggerated destruction of platelets caused by antiplatelet or drug-induced antibodies; and from severe blood loss.
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