Generic Arava

1. Denomination

Arava

2. Active Substance

Leflunomide

3. Indications for Use.

Arava is used as a basic remedy for the treatment of adults suffering from active form of rheumatoid arthritis, aiming in the reduction of disease symptoms and arrested development of structural damages of joints.

4. Action

Arava is a basic anti-rheumatic drug which takes anti-inflammatory action, likewise it acts on epithelial cells and suppresses immune reactions. It is used in capacity of a basic remedy for the treatment of adult patients suffering from active form of rheumatoid arthritis, aiming in the reduction of disease symptoms and arrested development of structural damages of joints. A clinical effect will appear after 4-6 weeks of administration and in the following may grow within 4-6 months.

5. Posology and Administration

Arava should be taken by mouth, the initial dose is 100 mg single-shot during 3 days, and then there will be a switch to a supportive treatment - 10-20 mg once a day. Tablets should be swallowed in whole, rinsing them with a sufficient quantity of liquid.
Arava performance in people of less than 18 years of age has not been studied. The data on Arava performance in elderly people (over 65 years of age) are limited enough, but they are alike of analogous parameters in younger people. 

6. Counterindications

Hypersensitivity, liver insufficiency, severe immunodeficiency (including AIDS), disorders of bone marrow blood formation, severe infections, moderate or severe kidneys insufficiency, low content of albumin in blood serum, pregnancy, reproductive age women (not using contraceptives during Leflunomide therapy), lactation period, age under 18.

7. Should Be Taken with Precautions, if…

The drug should be administered after a sound medical judgment by the specialists who have the experience requirement how to treat rheumatoid arthritis.
Patients should be notified of eventual rare but severe skin responses, likewise of the necessity of an urgent contact with a doctor in cases of emergence of skin rash or mucus coatings lesions.
Patients (men) should be warned about eventual gene mutations.

8. Interface with Other Medications

The drug is administered individually under a strict doctor’s control, if there is a need of simultaneous use of medications, a doctor’s advice is needed!

9. Overdosing

There is no data on overdosing of Arava (Leflunomide) or the intoxication induced by them.

10. Side Effects

On the part of cardiovascular system: typical: rise of arterial tension.
On the part of alimentary system: typical: diarrhea, nausea, vomit, anorexia, diseases of mucus coating of mouth cavity (stomatitis, lips cancering), pains in abdominal cavity: hepatitis, yellow sickness; very seldom: liver insufficiency, acute liver necrosis.
On the part of nervous system: typical: headache, dizziness, chronic fatigue, benumbed sensation, creeping sensation and tingling; non typical: taste disorders and anxiety.
On the part of musculoskeletal system: typical: inflammation of tendon sheath; non typical: ligament rupture.
On the part of urogenital system: the possibility of reversible reduction of sperm concentration, total number of spermatozoids and their mobility can not be excluded.
On the part of blood formation system, lymphatic system: typical: reduction in number of leucocytes in blood; non typical: anemia, reduction in number of thrombocytes; rarer: low content of all blood corpuscles; very seldom: the risk of development of malignant edemas,
Infections: development of severe infections and sepsis, enhances susceptibility to infections, a number of eventual infections may increase (rhinitis, bronchitis and pneumonia).
Dermatologic reactions: typical: intense hair loss, eczema, dry skin; non typical: blistering of the skin and mucus coatings, stripping of epidermis, ring-shaped spots on the skin.
Allergic reactions: typical: light allergic reactions, rash, itching; non typical: hives; very rare: allergic shock.
On the part of metabolic process: typical: weight loss (usually insignificant); rare: complete metabolism disorder.

11. Pregnancy and Lactation

The drug should not be administered during pregnancy and in women of child-bearing age who do not use reliable contraceptive tools. It is necessary to confirm pregnancy absence before the beginning of the treatment.
Patients should be informed that in case of assumption of pregnancy it is necessary to consult the doctor immediately and make a pregnancy test. If the test is positive, the doctor should inform the patient about an eventual risk for the fetus.
During Arava therapy breastfeeding is strongly prohibited.

12. Driving

Until you have not found out your reaction to the drug, do not do actions that will require alertness.

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Q. Can you tell me if I should be taking Generic Arava ( Leflunomide 10/20mg ) ? Or, will it work for me?
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