Generic Zantac

1. Denomination

Zantac

2. Active Substance

Ranitidine

3. Indications for Use.

The drug is used for the treatment of gastric and duodenal ulcer, including those connected with NSAID (Non-steroid anti-inflammatory drugs), after-surgery ulcers, peptic esophagitis, reflux disease pain syndrome, Zollinger-Ellison syndrome for preventive care of stress ulcers, bleeding relapses from peptic ulcer, Mendelson’s syndrome.

4. Action

Ranitidine action is based on the reduction of secretion of gastric juice. For the patient it is manifested in weakening, discomfort, suppression of the heartburn due to acidity reduction.

5. Posology and Administration

Posology and administration should be established individually. When there is oral treatment in adults and in children over 14 years of age, the daily dose should be 300-450 mg, if needed the daily dose may be increased up to 600-900 mg;  a repetition factor is 2-3 times/a day. As tool for prevention of aggravation of diseases there is used 150 mg/daily before bedtime. Length of the therapy is determined by indications to the use. Compromised function patients should be used 75 mg each 2 twice/daily.
Intramuscularly or intravenously Ranitidine should be used 50-100 mg each every 6-8 hours.

6. Counterindications

- pregnancy;
- lactation (breastfeeding);
- childhood under 14 years of age;
- hypersensitivity to Ranitidine.
Use limitations: liver cirrhosis, stomach cancer, compromised kidneys function.

7. Should Be Taken with Precautions, if…

Before the start of the treatment the presence of malignant neo formation should be excluded. Quick introduction of the drug in rare cases provokes bradycardia, usually in patients predisposed to heart rhythm disorder.

8. Interface with Other Medications

The use of such drugs requires a binding consultation or a doctor’s order,

9. Overdosing

Ranitidine takes a rather specific action, that is why an overdosing of the drug does not entail distinct consequences. But in the case of taking an odd dose it is necessary to visit a doctor.

10. Side Effects

On the part of digestive system: nausea, dry mouth, constipation, vomit, pain in the stomach, transient and reversible alterations of functional liver tests; in separate cases – development of hepatitis accompanied or non accompanied with jaundice (as a rule, a reversible one); seldom – diarrhea, acute inflammation of pancreatic gland.
Disordered blood formation function, as a consequence of its composition.
On the part of cardio-vascular system: decrease of arterial tension, arythmia, bradycardia, AV-blocking; seldom – system lesion of capillary vessels, arteries and veins.
On the part of CNS: headache (sometimes a strong one), dizziness, elevated fatigability, drowsiness; seldom – irritability, buzzing in ears, nebulosity of vision, involuntary reversible motor disturbances, involuntary motions predominantly in severely ill patients and in elderly ones – clouding of consciousness, depressions and hallucinations.
On the part of musculoskeletal system: seldom - pain in the joints, pain in the muscles.
Dermatologic reactions: loss of hair and baldness.
Allergic reactions: skin rash, hives, angioedema, allergic shock, bronchospasm, decrease of arterial tension, fever, pains in the chest.
On the part of endocrine system: severe pains in menstrual period, pains of mammary gland, delay of monthly periods, decrease of libido; seldom – reversible impotence, swelling or discomfort in breasts in men.

11. Pregnancy and Lactation

To pregnant women and to nursing mothers Ranitidine, as other drugs, can be administered only in cases of extreme necessity. Its use as a prophylaxis of renewal of gastric juice in the period of labor pains takes no side effects on the course of labor, or, further on in neonatal period.

12. Driving

In the course of treatment it is necessary to take caution in vehicle driving and in engagement of other potentially hazardous activities, if the drug reaction proceeds without distinct evidence, car driving is possible.

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Q. Can you tell me if I should be taking Generic Zantac ( Ranitidine 150/300mg ) ? Or, will it work for me?
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