1. Denomination
Zanaflex
2. Active Substance
Tizanidine
3. Indications for Use.
Painful spasms of muscles in spinal diseases,
after surgery of discal hernia or osteoarthritis of a hip,
spasticity and pains conditioned by neurologic diseases:
insular sclerosis,
chronic myelopathy,
degenerative diseases of spine,
stroke,
insult,
traumatic brain injuries,
cerebral palsy,
median convulsions.
4. Action
Relaxes skeleton muscles during chronic spastic states of spinal or cerebral origin, resolve acute painful muscle spasms and clonic convulsions. Decreases impedance of muscles with passive movements, increases the strength of arbitrary muscle contractions.
5. Posology and Administration
Optimal day’s dose is 12-14 mg (in 3-4 intakes), but not more than 36 mg. The dose is increasing gradually beginning with 2 mg 3 times a day. Gradual increase of a dose by 2 mg in every 3-7 days.
6. Counterindications
Hypersensitivity, frank failure of functions of liver and kidneys, pregnancy, breast feeding (ceased during treatment), childhood
7. Should Be Taken with Precautions, if…
A monitoring of function of liver and kidneys is needed; the doses should be reduced when the functions become worse.
8. Interface with Other Medications
Administration of Zanaflex together with the drugs which action is aimed on reducing of arterial tension, including urinatives, may sometimes provoke an excessive decrease of arterial tension and bradycardia.
Alcohol or sedatives may enhance the sedative action of Zanaflex.
9. Overdosing
To the present time there have been received several notices about overdosing of Tizanidine, including the case when a taken dose was 400 mg. In all the cases people recovered without exception.
Symptoms: nausea, vomiting, arterial hypotension, sleepiness, myosis, anxiety, respiration disturbance, coma.
Treatment. For excretion of the drug out of body multiply administration of activated coal is recommended. If overdosing is suspected immediately call a doctor.
10. Side Effects
While taking small doses recommended for stopping of muscle spasm, side effects emerge seldom, usually they are not frank and transitive. Often: sleepiness, weakness, dizziness, small decrease of arterial tension, dry mouth.
Seldom: nausea, gastroenteric upsets, transitive increase of activity of liver transaminases.
In administration of the higher doses recommended to cure spasticity, the above mentioned side effects emerge more often and are more frank, but they are rarely so severe to make the treatment ceased. Moreover, the following phenomenon may emerge:
Often: arterial hypotension, bradycardia.
Seldom: muscle weakness, insomnia, sleeping upsets, hallucinations.
Very seldom: acute hepatitis.
11. Pregnancy and Lactation
Counterindicated during pregnancy and breastfeeding.
12. Driving
Because of a possible sleepiness and weakness it is recommended the persons whose work requires quick physical and psychical reaction (operators of industrial machines, drivers etc) to limit the use of the drug.
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Q. How do I cancel my order of Zanaflex ( Tizanidine ) ?
A. If you wish to cancel your order, you must let us know before 11am EST the
following day. We will not be able to cancel any orders after this time. For all
cancellations, please contact us.
Q. Can you tell me if I should be taking Zanaflex ( Tizanidine ) ? Or, will it work for me?
A. We cannot advise you in any capacity in this matter. You should not take any
medication without consulting a physician first.
Q. What is your returns policy?
A. By law, we regret that we are unable to accept returned pharmaceuticals. If your purchase is defective in any way, we will be pleased to replace it at no cost to you.
Q. What is your refund policy
A. Refunds are solely at our discretion. If you are not satisfied with the product
or service provided, contact us immediately via email with your order number. We
will investigate and work hard to resolve the issue to your satisfaction.
Sometimes this can take up to 10 business days. If the matter cannot be
resolved, we will issue refunds as necessary.
Q. What is your cancellation policy
A. We debit your Credit Card only once we have shipped your order. Therefore, if
you wish to cancel your order prior to us charging your card you will be able to
do so without penalty. Once your order has been shipped we will be unable to
cancel your order.
Q. What about importing of Zanaflex ( Tizanidine ) to my country ?
A. Importation of prescription medication is legal in most countries (including the
US, UK, France, Spain, Hong Kong, Japan and S. Korea) provided the medication is
for personal use and is not a controlled substance. If you are in doubt about
the situation in your country, check with your local Post Office.