- Denomination
Vepesid
- Active Substance
Etoposide
- Indications for Use.
Herminogene seminima and oothecoma, cancer of lungs, cancer of adrenal cortex, cancer of urinary bladder, acute monoblastic leukemia, and that of myelogenous, lymphogranulomatosis, Non Hodgkin Lymphom, Kaposi’s sarcoma, Ewing’s sarcoma, cancer of stomach, chorionepithelioma, neuroblastoma.
- Action
The mechanism of Etoposide’s action lies in delay of DNA synthesis and, respectively in suppression of growth of tumor cells.
- Posology and Administration
Dosage regimen is set up in relation to the chemotherapy regimen in use. Intravenous drip-feed (it is dissolved in 0.9% solution of NaCl), during 30-60 minutes. It is administered in the following doses: 1) 100 mg/sq.m/daily from the 1-st to the 5-th day, the cycles should be repeated every 3-4 weeks; 2) 100-125 mg/sq.m in the 1-st, 3-d, 5-th days; the courses should be repeated in 3 weeks; 3) in oral intake 50 mg/sq.m. every day during 21 days, the cycles should be repeated every 4 weeks or 100-200 mg/sq.m 5 days running with a three weeks interval. Refresher courses of treatment should be carried out only after the factors of peripheral blood have been normalized. Before intravenous introduction it is dissolved in 250 ml of 0.9% solution of NaCl or 5% solution of dextrose up to the end concentration of 0.2-0.4 mg/ml. No contact with pH more than 8 buffered water solutions is allowed.
- Counterindications
Hypersensitivity, liver and/or kidney failure, bad distress of cerebral blood forming, acute infections of virus, fungal and bacterial nature (including herpes and chicken pox).
Alcoholism, epilepsy, childhood (less than 2 years of age, as security and efficiency for children has not yet been determined).
- Should Be Taken with Precautions, if…
With caution it should be taken in cases of arrythmia. Patients who suffer from kidney and liver failure need correction of dosage regimen and regular control of kidney function.
The drug should be taken only under a constant medical supervision. It is necessary to carry out a regular blood composition monitoring before the start of treatment, in intervals and before each successive course. If before the treatment there has been carried out radiation and/or chemo therapy, the choice of dosage regimen of Etoposide should be implemented in compliance with the evidence of bone marrow function distress.
While working with Etoposide safety whites, mask, glasses, gloves should be put on. In case of a contact with skin or mucus coating - impaired parts should be rinsed with water and soap immediately.
- Interface with Other Medications
Etoposide in no circumstances should be used without a doctor’s order. All the necessary recommendations on the use of this drug and eventual combination with other medications are under the responsibility of your attending doctor.
- Overdosing
There has not been yet registered a case of human Etoposide overdosing. It may be suggested that the main evidence of overdosage might be blood and intestinal tract toxic effects.
- Side Effects
Local reactions: phlebitis in case of intravenous introduction, in intravenous introduction and in penetration of the drug under the skin it may be locally-penetration action up to necrosis of surrounding tissues. On the part of blood forming organs fall of the number of leukocytes and granulocytes depends on the injected dose and it is the main toxic evidence that confines the dose.
On the part of digestive system: nausea, vomiting, moreover there are noticed diarrhea, abdominal pains, stomatitis, gullet inflammation, inflammatory processes of mouth cavity, gorge, gullet, larynx, anorexia. On the part of cardio-vascular system: temporary fall of arterial tension. Allergic reactions: chilly sensation, tachycardia, bronchial spasm, panting low arterial tension. On the part of skin integument: inversive baldness, sometimes it results in hair loss. Seldom: pigmentation, itching, radiation dermatitis. Others: seldom – drowsiness, increased fatigability, after-taste in mouth, cough as a consequence of lung disorders, malign exudative erythema (Stevens-Johnson syndrome), peeling, optic neuritis, amaurosis fugax of cortical genesis, muscle convulsions, metabolic acidosis, frequent nocturnal urination.
- Pregnancy and Lactation
It is counterindicated during pregnancy and in lactation period.
- Driving
The drug is not recommended to use for people who work as machinery operators of vehicle drivers.
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A. At this time, Vepesid ( Etoposide ) is sent through Registered Mail, which provides delivery confirmation but not real-time tracking.If you need to know the status of order Vepesid ( Etoposide ) or ask for a reshipment, please do not hesitate to get in touch with us.You are provided with real-time order status updates via our order status form, found on the left-hand side of the screen.
Q. How do I cancel my order of Vepesid ( Etoposide ) ?
A. If you wish to cancel your order, you must let us know before 11am EST the
following day. We will not be able to cancel any orders after this time. For all
cancellations, please contact us.
Q. Can you tell me if I should be taking Vepesid ( Etoposide ) ? Or, will it work for me?
A. We cannot advise you in any capacity in this matter. You should not take any
medication without consulting a physician first.
Q. What is your returns policy?
A. By law, we regret that we are unable to accept returned pharmaceuticals. If your purchase is defective in any way, we will be pleased to replace it at no cost to you.
Q. What is your refund policy
A. Refunds are solely at our discretion. If you are not satisfied with the product
or service provided, contact us immediately via email with your order number. We
will investigate and work hard to resolve the issue to your satisfaction.
Sometimes this can take up to 10 business days. If the matter cannot be
resolved, we will issue refunds as necessary.
Q. What is your cancellation policy
A. We debit your Credit Card only once we have shipped your order. Therefore, if
you wish to cancel your order prior to us charging your card you will be able to
do so without penalty. Once your order has been shipped we will be unable to
cancel your order.
Q. What about importing of Vepesid ( Etoposide ) to my country ?
A. Importation of prescription medication is legal in most countries (including the
US, UK, France, Spain, Hong Kong, Japan and S. Korea) provided the medication is
for personal use and is not a controlled substance. If you are in doubt about
the situation in your country, check with your local Post Office.
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