Generic Albenza

1. Denomination

Albenza

2. Active Substance

Albendazole

3. Indications for Use.

Pig’s tapeworm (тaenia solium) likewise its larval form.
Echinococcosis of lungs, abdominal membrane, provoked by larval form of dog’s tapeworm (Echinococcus granulosus).
Helminthosis of man provoked by parasitic threadworms - nematodes
Ascariasis is a disease provoked by the introduction of infection of ascarides, worms parasitic in man’s body (аscaris lumbricoides).
Trichocephaliasis is a helminthosis provoked by parasiting of whipworms,
Hookworms – ankylostomas (Ankylostoma duodenale) and necator (Necator americanus) are round helminths 5-12 mm of length and 0,5 mm of width.
Enterobiasis is a disease provoked by small parasitic worms, pinworms.
Strongyloidosis is an activator of tropical diarrhea (Strongyloides stercoralis) – diclinous round worms, chronic helminthosis.
Opisthorchosis (оpisthorchiidae), liver helminths (flukes, clonorchis)
Lambliosis - lamblias (Lamblia Intestinalis Jiardia) one-celled microscopic parasites.
Microspiriodosis – the small parasites ( мicrosporidium ) which form spores (0,5-2)х(1-4) mkm of dimension.
 Likewise mixed helminthoses.
 

4. Action

Albendazole is a wormer drug which provokes paralysis in parasites and results in their death. The drug is moderately toxic for people, but it endures well. On the starting step there is an insignificant decrement of the patient’s state, and then the state improves after a treatment course and clearing of the patient’s body from helmiths.

5. Phonology and Administration

Albendazole is administered individually in relation to diagnosis and age categories, likewise in relation to the patient’s body distinctions.
Medium therapeutic dose in nematodes therapy for adults and children over 2 years of age is 400 mg, single-shot.
In neurocycticercosis (Taenia solium) 400 mg 2 times/daily a course of treatment is 8-30 days. If the body mass is less than 60 kg a dose is to be set up on the basis of 15 mg/kg/daily divided into 2 intakes. The maximal daily dose is 800 mg
 In echinococcus (Echinococcus granulosus) patients with a body mass of 60 kg and more the drug is to be administered 400 mg 2 times/daily, with the body mass less than 60 kg a dose is to be set up on the basis of 15 mg/kg/daily divided into 2 intakes. The maximal daily dose is 800 mg; in echinococcus -  3 cycles 28 days each with a 14-days interval between the cycles.
In lambliosis (Lamblia Intestinalis Jiardia) cases in children the drug is to be administered on the basis of 10-15 mg/kg once/daily during 5-7 days.
In toxocarosis (Toxocara canis) in adults and children over 14 years of age with the body mass over 60 kg the drug is used in a single-shot dose of 400 mg; with the body mass less than 60 kg - 200 mg, in children less than 14 years of age a dose is set up on the basis of 10 mg/kg. Repetition factor is 2 times/daily, the therapy duration is 7-14 days.
The drug is to be taken during meal. It is recommended to have a simultaneous treatment for all the family members.

6. Counterindications

Hypersensitivity, pregnancy, lactation period, childhood (before 6 years of age the safety is not determined), suppression of marrowy blood formation, liver failure, liver cirrhosis, pathology of retina.

7. Should Be Taken with Precautions, if…

To be used with precaution in liver disorders (before the treatment and after it its functions should be controlled). It is recommended a control of a cellular composition of blood; if leucopenia emerges the therapy is to be suspended. In women of child-bearing age a test on non-pregnancy should be done before the drug therapy. A reliable contraception is obligatory during Albendazole therapy.

8. Interface with Other Medications

Concerning the combination of drugs see your attending doctor.

9. Overdosing

In cases of overdosage symptoms of side effects are substantially enhanced, if the patient has such developments it is well to seek a medical care right away.

10. Side Effects

On the part of intestinal system: pain in stomach, nausea, vomiting. On the part of nervous system: headache, dizziness. Allergic reactions: skin rash, itching. Other side effects: unstable arterial tension, disorders of kidneys function, loss of hair, acute kidney failure.

11. Pregnancy and Lactation

The drug is counterindicated for the use during pregnancy. If the administration of the drug is drastically needed it is got to consider over termination of breastfeeding.
Before the drug administration it is necessary to make sure that a woman of child-bearing age is not pregnant. Reliable contraception methods are well to be used during Albendazole therapy.

12. Driving

During Albendazole therapy it is not recommended to drive vehicles, especially in the starting period of treatment.

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